I am using Megan CE version 6.21.1 with long read metagenomic sequences to analyze the functional composition of the metagenome. I am finding that many InterPro annotations are incorrect. I have included one example here. Megan assigned WP_148073251.1 as IPR039808 cadherin. When I use the protein sequence to perform an InterPro scan, it does not match to cadherin. The read aligns quite well with the protein ID WP_148073251.1; however, the assigned InterPro identifier seems incorrect. I have attached the screenshot below. Please suggest.
Hi, I just wanted to follow up and inquire about any suggestions regarding the interpro annotation mentioned earlier. It occurred with multiple annotations. Please let me know if you require additional information.